The International Conference on Health Big Data and Food Safety 2025 (HBDFS 2025) is about to grandly open in Guangzhou, an international metropolis. As a landmark event in the field of global health big data and food safety, this conference will attract public health experts, data scientists, food safety professionals, and policy makers from around the world to come together to explore how to promote public health through advanced data analysis technology and ensure food safety. The theme of the conference is "data-driven innovation, technology ensures health", aiming to provide a platform for participants to exchange ideas, share the latest research results, and explore opportunities for cooperation. The activities are rich and colorful, including themed speeches, symposiums, interactive workshops, poster displays, etc., covering multiple aspects from the acquisition, analysis, and application of health big data to food safety supervision strategies. Special attention is paid to topics such as the role of big data in personalized healthcare, the impact of emerging technologies on food supply chain transparency, and the potential of artificial intelligence in health management. Guangzhou, as the southern gateway of China, is an ideal place to host this conference due to its unique geographical location and profound cultural heritage. In recent years, Guangzhou has made significant achievements in promoting the construction of a healthy city and food safety management, which provides rich practical cases and research materials for HBDFS 2025. In addition, the conference will also set up a student forum to encourage young scholars to participate in showcasing their research results and engage in in-depth exchanges with top experts in the industry. In addition to professional academic exchanges, HBDFS 2025 also plans to organize a series of cultural experience activities to give participants the opportunity to appreciate the charm of Guangzhou, an ancient yet modern city. We sincerely invite people from all walks of life to actively participate in HBDFS 2025, share this knowledge feast, work together to promote the development of global health big data and food safety, and create a better future for human health. Let's gather in Guangzhou and embark on a meaningful journey of knowledge.